The p62 UBA is unique amongst UBAs since it exists as a highly stable dimer but binds to ubiquitin as a monomer. The dimerization interface partially occludes the ubiquitin binding interface resulting in competing equilibria. The factors which regulate the affinity of p62 UBA were examined in this thesis.In isolated p62 UBA the monomer dimer equilibrium and the effects of phosphorylation were investigated.
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